Jay Alexander Moore
Computational biology • Neurodegeneration • Agentic AI
Interests
Interdisciplinary researcher studying data and genomics in human health. My best experiences have had these in common:
- Hands on work with the latest technology
- Working with engaged and excited people
- Learning about the complex biology that drives our lives
Positions
- Oct 2025–present UKDRI • Imperial College London Research Assistant @ Neurogenomics Lab
- 2025 University College London MSc, Personalised Medicine and Novel Therapies (Distinction)
- Oct 2022–Mar 2025 Curileum Discovery Ltd Biomedical Scientist • Drug discovery startup
- Jul 2018–Jul 2022 Foundation Medicine Inc. Scientist I / Senior Research Associate / Research Associate $5.3B acquisition by Roche
Publications
- Pan-cancer analysis of copy-number features identifies recurrent signatures and a homologous recombination deficiency biomarker to predict poly (ADP-ribose) polymerase inhibitor response
- A novel HRD signature is predictive of FOLFIRINOX benefit in metastatic pancreatic cancer
- Comprehensive genomic profiling and treatment patterns across ancestries in advanced prostate cancer: a large-scale retrospective analysis
- Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histologic transformation
- The molecular landscape of pancreatobiliary cancers for novel targeted therapies from real-world genomic profiling
- Somatic HLA class I loss is a widespread mechanism of immune evasion which refines the use of tumor mutational burden as a biomarker of checkpoint inhibitor response
- Prediction and characterization of diffuse large B-cell lymphoma cell-of-origin subtypes using targeted sequencing
- Genomic profiling of combined hepatocellular cholangiocarcinoma reveals genomics similar to either hepatocellular carcinoma or cholangiocarcinoma
- The Molecular Landscape of Gastric Cancers for Novel Targeted Therapies from Real-World Genomic Profiling
- Genomic Profiling of Small Intestine Cancers From a Real-World Data Set Identifies Subgroups With Actionable Alterations
- Poor prognosis among radiation-associated bladder cancer is defined by clinicogenomic features
Patents
Websites
Personal Genomics Reporting
Research workbench for AI genetics reporting
Test how reporting templates change AI interpretation of genetic screening results using consented PGP genomes.
personalgenomes.jaydata.bio →
Chaos Chess
Chess where reality shifts
Every few moves the board transforms into a different position with the same evaluation. Play fast between chaos events to earn an eval bonus.
chaos-chess.jaydata.bio →
Fix My Lab Protocol
AI protocol analyser
Upload a lab protocol and get AI-powered feedback — flagged issues, optimisation suggestions with literature references, and PubMed search.
fix-my-lab-protocol.jaydata.bio →